Effect of diabetes mellitus on outcome in patients with traumatic brain injury: A national trauma databank analysis.
| Autor: | Lustenberger, Thomas, Talving, Peep, Lam, Lydia, Inaba, Kenji, Bass, Margarita, Plurad, David, Demetriades, Demetrios |
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| Předmět: |
BRAIN injury treatment
ARTIFICIAL respiration BRAIN injuries CHI-squared test COMPARATIVE studies CONFIDENCE intervals DIABETES REPORTING of diseases EPIDEMIOLOGY FISHER exact test LENGTH of stay in hospitals HOSPITALS LONGITUDINAL method EVALUATION of medical care DEATH rate NOSOLOGY PROBABILITY theory SCALES (Weighing instruments) U-statistics COMORBIDITY LOGISTIC regression analysis DATA analysis DISCHARGE planning DATA analysis software DESCRIPTIVE statistics GLASGOW Coma Scale TRAUMA severity indices |
| Zdroj: | Brain Injury; Mar2013, Vol. 27 Issue 3, p281-285, 5p |
| Abstrakt: | Background: Diabetes mellitus (DM) is associated with worsened outcomes following severe injury. However, clinical studies evaluating the effect of DM on outcomes in patients suffering traumatic brain injury (TBI) are currently lacking. Methods: This was a National Trauma Databank (NTDB) study over a 5-year period. Patients with DM were matched with victims of isolated TBI without DM in a 1:2 ratio. Outcomes included mortality, hospital and surgical intensive care unit (SICU) length of stay, ventilator days and discharge disposition. Results: Of the 35 005 patients with isolated TBI, 636 (1.8%) cases had documented DM. After matching 1272 counterparts without DM, no differences with regards to demographic and injury characteristics were observed comparing the two groups. Overall mortality in the study population was 18.8% ( n = 358), with a significantly increased in-hospital mortality in patients with vs without DM [22.6% vs 16.8%; OR (95% CI): 1.45 (1.14-1.83); p = 0.002]. Patients with DM were significantly less frequently discharged home compared to their counterparts without DM [38.9% vs 46.1%; OR (95% CI): 0.75 (0.60-0.93); p = 0.008]. Conclusion: Traumatic brain injury in conjunction with diabetes mellitus is associated with an almost 1.5-fold increased mortality while compared to patients with isolated TBI without diabetes mellitus. Prospective validation of these findings is warranted to determine the underlying aetiology. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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