HLA-DQ3 is associated with idiopathic guttate hypomelanosis, whereas HLA-DR8 is not, in a group of renal transplant patients.

Autor: Arrunategui, Adriana, Trujillo, Rodolfo A., Marulanda, Maria P., Sandoval, Fabian, Wagner, Adriana, Alzate, Alberto, Falabella, Rafael
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Zdroj: International Journal of Dermatology; Nov2002, Vol. 41 Issue 11, p744-747, 4p
Abstrakt: Abstract Background The etiology of idiopathic guttate hypomelanosis (IGH) remains uncertain; however, solar exposure and heredity have been proposed as causative factors. Objective To explore the genetic predisposition to the development of IGH. Methods A comparative case–control study was performed at a dermatology department at a university hospital. Forty-seven subjects (22 renal transplant patients and 25 controls) were enrolled. Clinical examination and human leukocyte antigen (HLA) determination were performed. Results In the group of subjects with HLA-DQ3 (10/13, P = 0.025), there was a statistically significant (P < 0.05) positive association for the presence of IGH; in the group of subjects with HLA-DR8 (6/6, P = 0.023), there was a statistically significant negative association for the presence of IGH. Conclusions The presence of HLA-DQ3 in patients with IGH suggests a genetic basis in a group of renal transplant subjects. HLA-DR8 was found in patients without IGH, and it could play a role as a “protective factor” preventing subjects from developing IGH. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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