| Autor: |
Sambasiva Rao, P., Kurumurthy, C., Veeraswamy, B., Santhosh kumar, G., Narsaiah, B., Pranay Kumar, K., Murthy, U., Karnewar, Santosh, Kotamraju, Srigiridhar |
| Zdroj: |
Medicinal Chemistry Research; Apr2013, Vol. 22 Issue 4, p1747-1755, 9p |
| Abstrakt: |
A series of novel 1,2,3-thiadiazolo-5-carboxylic acid hydrazide Schiff's bases 4a- 4r were prepared starting from ethyl-4,4,4-trifluoroacetoacetate and ethyl carbazate in four steps. All the compounds were screened for antibacterial activity against various bacterial strains at 150 μg/ml concentration and found no activity. Similarly, all the compounds were screened for antifungal activity against various fungal strains at 100 and 150 μg/ml concentrations. Compounds 4a, 4m, and 4q found to show moderate activity against Candida albicans. Further, compounds were evaluated for cytotoxic activity against breast carcinoma cells MDA-MB 231 (aggressive), MCF-7 (non-aggressive) using doxorubicin as standard. Compound 4n was found to show 25.39 % cell viability against MDA-MB 231 and 63.60 % cell viability against MCF-7 cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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