Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study.

Autor: Hecking, Erwin, Köhler, Heide, Zobel, Rainer, Lemmel, Ernst.-M., Mader, Hans, Opferkuch, Wolfgang, Prellwitz, Winfried, Keim, Hans J., Müller, Doris
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Zdroj: American Journal of Clinical Nutrition; Oct1978, Vol. 31 Issue 10, p1821-1826, 6p, 3 Charts, 3 Graphs
Abstrakt: Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protein per kilogram of body weight appears sufficient for patients on hemodialysis. Treatment with essential amino acids offers no advantage [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index