| Autor: |
Mazurov, A.V., Pevzner, D.V., Antonova, O.A., Byzova, T.V., Khaspekova, S.G., Semenov, A.V., Vlasik, T.N., Samko, A.N., Staroverov, I.I., Ruda, M.Ya. |
| Předmět: |
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| Zdroj: |
Platelets; Dec2002, Vol. 13 Issue 8, p465-477, 13p |
| Abstrakt: |
The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab′)[sub 2] fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab′)[sub 2] FRaMon) upon its intravenous administration in patients undergoing high-risk coronary angioplasty. Patients were treated before angioplasty with F(ab′)[sub 2] FRaMon at 0.2 mg/kg (n = 17) and 0.25 mg/kg (n = 12) bolus or with abciximab at 0.25 mg/kg bolus + 12 h infusion at 0.125 μg/kg per min (n = 29). F(ab′)[sub 2] FRaMon at both doses decreased platelet aggregation induced by 20 μM ADP to <10, <20, <40 and <70% of the predrug level at 1, 12, 24 and 72 h after injection, respectively. No significant differences were observed between F(ab′)[sub 2] FRaMon and abciximab antiaggregatory effects. In none of the patients did F(ab′)[sub 2] FRaMon cause allergic reactions, major bleedings or deep thrombocytopenia. Antibodies against F(ab′)[sub 2] FRaMon were detected in one patient. Free F(ab′)[sub 2] FRaMon was cleared from plasma within 12 h, while platelet-bound preparation occupied >95, 70-80 and 40-50% of GP IIb-IIIa at 1 and 12-24 h and 3 days after injection, respectively. Thrombotic complications within the first month after angioplasty in groups treated with F(ab′)[sub 2] FRaMon and abciximab were observed in one and two patients, respectively. The data obtained have shown that F(ab′)[sub 2] FRaMon at bolus administration to patients undergoing coronary angioplasty caused no serious side effects and at comparative dosage inhibited platelet aggregation with the same efficacy as abciximab at bolus + infusion administration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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