Boron-Containing Peptidomimetics - A Novel Class of Selective Anti-tubercular Drugs.

Autor:	Gorovoy, Alexey S., Gozhina, Olga V., Svendsen, John S., Domorad, Anna A., Tetz, George V., Tetz, Victor V., Lejon, Tore
Předmět:	PHYSIOLOGICAL effects of boron PEPTIDOMIMETICS ANTITUBERCULAR agents BORONIC acids ANTIBACTERIAL agents MYCOBACTERIUM tuberculosis
Zdroj:	Chemical Biology & Drug Design; Mar2013, Vol. 81 Issue 3, p408-413, 6p, 2 Diagrams, 2 Charts
Abstrakt:	Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, new antibiotics are in great need. Here, we report the synthesis and in vitro testing of a new class of highly selective antimicrobial boron-containing peptidomimetics with compounds exhibiting activity against Mycobacterium tuberculosis at ≤5 μg/mL. The new approach developed makes it possible to synthesize variously substituted β-aminoboronic acids and their derivatives with a high level of diastereoselectivity. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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