EFFECT OF CHRONIC MORPHINE ADMINISTRATION ON GLUCOSE TOLERANCE AND INSULIN BINDING TO ISOLATED RAT ADIPOCYTES.

Autor:	Sood, Ajay, Sood, A., Thakur, V. S., Karmarkar, M. G., Ahuja, M. M. S.
Předmět:	MORPHINE GLUCOSE tolerance tests RATS
Zdroj:	Endocrine Research; Feb2001, Vol. 27 Issue 1/2, p215-221, 7p
Abstrakt:	Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p <0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of [SUP125]I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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