| Autor: |
Koester, L. S., Guterres, S. S., Le Roch, M., Eifler-Lima, V. L., Zuanazzi, J. A., Bassani, V. L. |
| Předmět: |
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| Zdroj: |
Drug Development & Industrial Pharmacy; Jul2001, Vol. 27 Issue 6, p533-540, 8p, 2 Charts |
| Abstrakt: |
Ofloxacin (OFX) is a fluorquinolone characterized by photochemical instability. With the goal to improve its photostability in aqueous solutions, the complexation of ofloxacin with β-cyclodextrin was investigated. The complexes showed a water solubility enhancement of approximately 2.6 times; nevertheless, the photodegradation of ofloxacin was not reduced. The complexes obtained were characterized by thermal and [SUP1]H nuclear magnetic resonance (NMR) analysis, which revealed an interaction between ofloxacin and β-cyclodextrin. The last analysis indicated that only parial inclusion of the N-methylpiperazinyl moiety occurred, which can explain the fact that photostabilization was not improved. This partial inclusion phenomenon could be explained also by computer-aided molecular modeling. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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