| Autor: |
Movafagh, Abolfazl, Hashemi, Mehrdad, Ghadiani, Mojtaba, Mirfakhraei, Reza, Darvish, Hossein, Zare Abdollahi, Davood, Ghaedi, Hamid, Safari, Shamsi, HaghNejad, Leyla, Mosammami, Sara, Safavi Naeini, Niloofar, Miri, Ramin, Rezaei Tavirani, Mostafa |
| Předmět: |
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| Zdroj: |
Middle East Journal of Cancer; Apr-Jul2012, Vol. 3 Issue 2/3, p85-88, 4p, 1 Diagram, 1 Graph |
| Abstrakt: |
Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. Methods: We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/ chromosomes/Mitelman) databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone marrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique. Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex karyotype 46,XX,t(9;22;2;5). Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding these translocations in leukemias. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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