A patient with paroxysmal nocturnal haemoglobinuria in whom granulocyte colony-stimulating factor administration resulted in improvement of recurrent enterocolitis and its associated haemolytic attacks.

Autor: Fujimi, Akihito, Matsunaga, Takuya, Kogawa, Katsuhisa, Ohnuma, Takayuki, Takahira, Naoki, Abe, Tomoyuki, Kitaoka, Keisuke, Kogawa, Takahiro, Tanaka, Ikuta, Morii, Kazuhiro, Terui, Takeshi, Sakamaki, Sumio, Kato, Junji, Kura, Toshiro, Maeda, Takeshi, Niitsu, Yoshiro
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Zdroj: British Journal of Haematology; Dec2002, Vol. 119 Issue 3, p858-862, 5p
Abstrakt: Summary. We report an elderly patient with paroxysmal nocturnal haemoglobinuria (PNH), having recurrent enterocolitis and haemolytic attacks associated with cellular immunodeficiency. On admission, the patient had normal neutrophil count and function but a decreased T-cell count, decreased mitogenic reactions, and a negative tuberculin test. Granulocyte colony-stimulating factor (G-CSF) was administered, resulting in an increased T-cell count, normalization of T-cell function, increased blood levels of helper T cell (Th)1 and Th2 cytokines and improvement in the enterocolitis and haemolytic attacks. This suggests that G-CSF may be useful in the treatment of elderly PNH patients with cellular immunodeficiency. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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