Medication Persistence of HIV-infected Drug Users on Directly Administered Antiretroviral Therapy.
Autor: | Ing, Eileen, Bae, Jason, Maru, Duncan, Altice, Frederick |
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Předmět: |
CONFIDENCE intervals
MENTAL depression DRUGS EPIDEMIOLOGY HIV infections LONGITUDINAL method PATIENT compliance RESEARCH funding SCALES (Weighing instruments) SURVIVAL analysis (Biometry) LOGISTIC regression analysis DATA analysis ANTIRETROVIRAL agents RANDOMIZED controlled trials DATA analysis software DESCRIPTIVE statistics |
Zdroj: | AIDS & Behavior; Jan2013, Vol. 17 Issue 1, p113-121, 9p, 1 Illustration, 2 Charts, 1 Graph |
Abstrakt: | Patient and regimen persistence in HIV-infected drug users are largely unknown. We evaluated patterns of medication non-persistence among HIV-infected drug users enrolled in a prospective, 6-month randomized controlled trial of directly administered antiretroviral therapy (DAART). Medication-taking behavior was assessed via direct observation and MEMS data. Of 74 participants who initiated DAART, 59 (80%) subjects were non-persistent with medication for 3 or more consecutive days. Thirty-one participants (42%) had 2 or more episodes of non-persistence. Higher depressive symptoms were strongly associated with non-persistence episodes of ≥ 3 days (AOR: 17.4, P = 0.02) and ≥ 7 days AOR: 5.4, P = 0.04). High addiction severity (AOR 3.2, P = 0.03) was correlated with non-persistence ≥ 7 days, and injection drug use (AOR: 15.2, P = 0.02) with recurrence of non-persistence ≥ 3 days. Time to regimen change was shorter for NNRTI-based regimens compared to PI-based ones (HR: 3.0, P = 0.03). There was no significant association between patterns of patient non-persistence and virological outcomes. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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