| Autor: |
Atzpodien, Jens, Kirchner, Hartmut, Körfer, Alfred, Hadam, Martin, Schomburg, Axel, Menzel, Thomas, Deckert, Markus, Franzke, Anke, Volkenandt, Matthias, Dallmann, Iris, Grosse, Jens, Poliwoda, Hubert |
| Zdroj: |
Tumor Biology (Springer Science & Business Media B.V.); 1993, Vol. 14 Issue 6, p354-359, 6p |
| Abstrakt: |
Natural killer (NK) cells are believed to contribute to the clinical efficacy of cancer immunotherapy using recombinant interleukin-2 (rIL·2) in humans. In previous trials of high-dose i.v. rIL-2, however, no correlation has been established between circulating NK cells and treatment response. Between January 1989 and October 1990, we treated a total of 47 outpatients with advanced tumors using low-dose s.c. rIL·2 and interferon-α-2 (rIFN-α). Therapy consisted of a 2-day rIL·2 pulse at 18 million IU/m2/ day, followed by 6 weeks of rIL-2 (3.6 × 106-4.8 × 106 IU/m2/day × 5 days/week) and rIFN-α (5 × 106-6 × 106U/m2 × 3/week). Before and after therapy, we phenotypically evaluated circulating lymphocytes and correlated them with clinical response. During 6-week therapy, peripheral blood lymphocytes bearing the CD 5 6 (NK-cell-associated) surface antigen were increased significantly (p < 0.005) in treatment responders [complete response (CR) and partial response (PR), n = 10; 3.8-fold] and stable disease (SD) patients (n = 20; 2.1-fold), while patients with progressive disease (PD, n = 17) exhibited no significant expansion of circulating NK cells (p > 0.1). After one 6-week treatment cycle, CR/PR patients had significantly more peripheral NK cells, when compared with patients in SD (1.6-fold) and PD (1.9-fold) (p < 0.04). The overall number of circulating lymphocytes was also increased upon therapy (1.6-fold; p ≤ 0.001), but remained independent of response (p > 0.4). These data demonstrate that s.c. rIL·2 and s.c. rIFN-α produce a significant increase in peripheral blood NK cells; this expansion correlates significantly with treatment response in advanced tumor patients receiving long-term combination immunotherapy at outpatient doses. Copyright © 1993 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
