Co-Morbidities in Persons Infected with HIV: Increased Burden with Older Age and Negative Effects on Health-Related Quality of Life.
| Autor: | Rodriguez-Penney, Alan T., Iudicello, Jennifer E., Riggs, Patricia K., Doyle, Katie, Ellis, Ronald J., Letendre, Scott L., Grant, Igor, Woods, And The Hiv Neurobehavioral Research Program (hnrp) Group, Steven Paul |
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| Předmět: |
QUALITY of life
HEALTH AGE distribution HEALTH surveys HIV infections INTELLIGENCE tests INTERVIEWING NEUROPSYCHOLOGICAL tests RESEARCH methodology NONPARAMETRIC statistics RESEARCH funding SCALES (Weighing instruments) SELF-evaluation STATISTICS COMORBIDITY DATA analysis MULTIPLE regression analysis SEVERITY of illness index DATA analysis software DESCRIPTIVE statistics |
| Zdroj: | AIDS Patient Care & STDs; Jan2013, Vol. 27 Issue 1, p5-16, 12p, 4 Charts, 2 Graphs |
| Abstrakt: | This study sought to determine the synergistic effects of age and HIV infection on medical co-morbidity burden, along with its clinical correlates and impact on health-related quality of life (HRQoL) across the lifespan in HIV. Participants included 262 individuals across four groups stratified by age (≤40 and ≥50 years) and HIV serostatus. Medical co-morbidity burden was assessed using a modified version of the Charlson Co-morbidity Index (CCI). Multiple regression accounting for potentially confounding demographic, psychiatric, and medical factors revealed an interaction between age and HIV infection on the CCI, with the highest medical co-morbidity burden in the older HIV+cohort. Nearly half of the older HIV+group had at least one major medical co-morbidity, with the most prevalent being diabetes (17.8%), syndromic neurocognitive impairment (15.4%), and malignancy (12.2%). Affective distress and detectable plasma viral load were significantly associated with the CCI in the younger and older HIV-infected groups, respectively. Greater co-morbidity burden was uniquely associated with lower physical HRQoL across the lifespan. These findings highlight the prevalence and clinical impact of co-morbidities in older HIV-infected adults and underscore the importance of early detection and treatment efforts that might enhance HIV disease outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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