| Autor: |
Orajärvi, Marko, Puijola, Elina, Shi-Bin Yu, Xiaodong Liu, Tiilikainen, Petri, Meiqing Wang, Raustia, Aune, Pirttiniemi, Pertti |
| Předmět: |
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| Zdroj: |
Journal of Orofacial Pain; Fall2012, Vol. 26 Issue 4, p328-336, 9p, 2 Color Photographs, 2 Graphs |
| Abstrakt: |
Aims: To study the effect of estrogen deficiency and altered temporomandibular joint loading on the histomorphology of condylar cartilage and on the expression of types II and X collagen and matrix metalloproteinase-3 (MMP-3). Methods: Thirty-six female rats were divided into four groups: ovariectomized rats on a normal diet, nonovariectomized control rats on a normal diet, ovariectomized rats on a soft diet, and nonovariectomized control rats on a soft diet. Ovariectomy was performed at the age of 60 days. Repeated-measures ANOVA was used to analyze the data. Results: The condylar cartilage in the ovariectomized normal diet group showed a significantly higher number of cells than in the nonovariectomized control rats (P < .001). The proportional amount of MMP-3 expression was significantly higher in the ovariectomized rats than in the nonovariectomized control rats in both diet groups (P < .001). The area covered by types II and X collagen was significantly higher in the experimental groups than in the control groups (P < .01). Conclusion: Condylar cartilage is sensitive to both estrogen level and dietary loading. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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