| Autor: |
Korkusuz, Huedayi, Ulbrich, Karsten, Bihrer, Verena, Welzel, Katerina, Chernikov, Valery, Knobloch, Thomas, Petersen, Sabine, Huebner, Frank, Ackermann, Hanns, Gelperina, Svetlana, Korkusuz, Yuecel, Kromen, Wolfgang, Hammerstingl, Renate, Haupenthal, Jorg, Fiehler, Jens, Zeuzem, Stefan, Kreuter, Jorg, Vogl, Thomas J., Piiper, Albrecht |
| Předmět: |
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| Zdroj: |
Molecular Imaging; Jul/Aug2012, Vol. 11 Issue 4, p272-279, 8p |
| Abstrakt: |
Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd- HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor-expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain (p = .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver (p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP (p = .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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