| Abstrakt: |
The objective of this study is to describe the management of two adults with laryngeal mucosa-associated lymphoid tissue (MALT) lymphoma and concurrent bronchial MALT lymphoma and to review the literature pertaining to laryngeal lymphoma and discuss appropriate evaluation and treatment options. This is a retrospective case series where a retrospective chart review was performed. Demographic data collected includes presenting symptoms, age at presentation, gender, comorbidities, course of illness, and follow-up. Operative reports, serial endoscopic examinations, and serial CT images were used to monitor for recurrence. Between 2004 and 2006, two adult subjects were diagnosed and treated for false vocal cord MALT lymphoma with concurrent low-grade bronchial MALT lymphoma. Both patients were treated with surgical debulking, adjunctive rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (RCHOP) chemotherapy, and external beam radiation. At most recent follow-up, there was no endoscopic, clinical, or radiologic evidence of recurrence. Surgical debulking, RCHOP chemotherapy, and external beam radiation show promising results in treating false vocal cord laryngeal MALT lymphomas with concurrent low-grade bronchial MALT lymphomas. Bronchoscopy and laryngoscopy should be included in the evaluation of a patient with a laryngeal or bronchial MALT lymphoma for staging and optimal treatment since MALT lymphoma can be multifocal in both larynx and bronchus as shown in this case series. [ABSTRACT FROM AUTHOR] |
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