| Autor: |
Stepien, Cathie J., Gross, Kenneth B., Batterman, Stuart A., Franzblau, Alfred, D'Arcy, James B., Schreck, Richard M., Zhou, Nathan, Sargent, Nicholas E. |
| Předmět: |
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| Zdroj: |
Applied Occupational & Environmental Hygiene; May1997, Vol. 12 Issue 5, p367, 0p |
| Abstrakt: |
Biological monitoring of exposure to industrial chemicals commonly involves laboratory analyses of a toxicant or metabolites in urine. The American Conference of Governmental Industrial Hygienists has recommended biological exposure indices for methanol exposure based on methanol and formate in urine. The present study was designed primarily to evaluate methanol in urine and other potential biological determinants of methanol exposure. Volunteer subjects underwent controlled exposure to methanol vapor at different concentrations for approximately 8 hours to simulate a standard work shift. Urine was collected immediately prior to exposure sessions, during exposures, and immediatelyfollowing cessation of exposures. Samples were analyzed for methanol, formate, specific gravity (SpGr), and creatinine. The following biological determinants were examined: total methanol excreted during the shift; mean concentration of methanol excreted during the shift (uncorrected, and corrected for SpGr and creatinine); and concentration of methanol and formate excreted in urine immediately following cessation of exposure (again uncorrected, and corrected for SpGr and creatinine). All methanol-based parameters were approximately linearly related to exposure concentration, but the results for formate related poorly to exposure. In addition, there was considerable interindividual variation in all measured parameters. Overall, measurement of formate in urine was not a useful indicator of individual or group methanol exposures in the range of the permissible exposure limit of 200 ppm. Because of large interindividual variation, methanol in urine (i.e., concentration at end of shift or mean concentration excreted acrossshift) would not appear suitable for quantitative assessment of individual exposures, but methanol in urine would appear useful as a semiquantitative or qualitative index of individual exposure, or to assess quantitatively the methanol exposure of a group. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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