| Autor: |
Irwin, Gilbert R., Hierholzer, Walter J., McCollum, Robert W., Irwin, G R Jr, Hierholzer, W J Jr, McCollum, R W |
| Zdroj: |
Journal of Infectious Diseases; 1972, Vol. 125 Issue 1, p73-76, 4p |
| Abstrakt: |
A model for the study of delayed hypersensitivity to hepatitis-associated antigen (HAA) in guinea pigs was designed. Guinea pigs immunized with purified HAA plus Freund's complete adjuvant developed a positive skin reaction when they were inoculated intradermally with HAA 17 to 35 days later. This reaction is characterized by erythema and induration that reaches a maximum at 24 to 36 hr and then subsides over the next 48 hr. Histologic examination of the skin lesions shows an infiltrate of predominantly mononuclear cells. Heating HAA for 1 min at 37 C, 57 C, 75 C, or 98 C does not modify its activity as an immunizing or skin-reactive agent. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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