| Autor: |
Kastello, Michael D., Eddy, Gerald A., Kuehne, Ralph W., Kastello, M D, Eddy, G A, Kuehne, R W |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1976, Vol. 133 Issue 1, p57-62, 6p |
| Abstrakt: |
Two groups of rhesus monkeys were inoculated with either 105 (group 1) or 103 (group 2) plaque-forming units of Machupo virus, the etiologic virus of Bolivian hemorrhagic fever. The monkeys were observed for clinical signs; body temperatures, viremias, hematologic changes, and virus-neutralizing antibody were measured. The onset of clinical signs for groups 1 and 2 occurred on days 4–6 and 7–10, respectively, with fever, anorexia, and depression. These and other signs became more severe, and all of the monkeys died; the respective mean times to death for groups 1 and 2 were 14.3 and 19.5 days. Hematocrit, neutrophil, and lymphocyte values decreased in both groups until a few days before death and then increased slightly. Viremias in the two groups peaked on days 13 and 16, respectively, and persisted until death; the sole exception was one monkey in group 2 that developed neutralizing antibody by day 21. The response of the rhesus monkey to Machupo virus thus provides a useful model for the study of Bolivian hemorrhagic fever. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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