15Chromium-Release Microassay Technique for Cell-Mediated Immunity to Mumps Virus: Correlation with Humoral and Delayed-Type Skin Hypersensitivity Responses.

Autor: Rola-Pleszczynski, Marek, Vincent, Monroe M., Hensen, Sally A., Walser, Judith, Crawford, Margaret, Bellanti, Joseph A.
Zdroj: Journal of Infectious Diseases; 1976, Vol. 134 Issue 6, p546-551, 6p
Abstrakt: Lymphocyte-mediated immune responsiveness to mumps virus was studied with use of a 51chromium (51Cr)-re1ease microassay of Iymphocytotoxicity to target cells persistently infected with mumps virus. The release of 51Cr from immune cells was found to be virus-specific and reproducible and correlated well with the presence of antibody but not with the magnitude of antibody levels. Delayed-type skin hypersensitivity and specific immune release of 15Cr did not correlate well, which suggests that the two events may be mediated by different populations of cells. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index