| Autor: |
Zhuang, Yuan, Peng, Liu-sheng, Zhao, Yong-liang, Shi, Yun, Mao, Xu-hu, Guo, Gang, Chen, Weisan, Liu, Xiao-fei, Zhang, Jin-yu, Liu, Tao, Luo, Ping, Yu, Pei-wu, Zou, Quan-ming |
| Předmět: |
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| Zdroj: |
Cancer Immunology, Immunotherapy; Nov2012, Vol. 61 Issue 11, p1965-1975, 11p |
| Abstrakt: |
IL-22-producing CD4 T cells (IL-22CD4 T cells) and Th22 cells (IL-22IL-17IFN-γCD4 T cells) represent newly discovered T-cell subsets, but their nature, regulation, and clinical relevance in gastric cancer (GC) are presently unknown. In our study, the frequency of IL-22CD4 T cells in tumor tissues from 76 GC patients was significantly higher than that in tumor-draining lymph nodes, non-tumor, and peritumoral tissues. Most intratumoral IL-22CD4 T cells co-expressed IL-17 and IFN-γ and showed a memory phenotype. Locally enriched IL-22CD4 T cells positively correlated with increased CD14 monocytes and IL-6 and IL-23 detection ex vivo, and in vitro IL-6 and IL-23 induced the polarization of IL-22CD4 T cells in a dose-dependent manner and the polarized IL-22CD4 T cells co-expressed of IL-17 and IFN-γ. Moreover, IL-22CD4 T-cell subsets (IL-22IL-17CD4, IL-22IL-17CD4, IL-22IFN-γCD4, IL-22IFN-γCD4, and IL-22IL-17IFN-γCD4 T cells), and Th22 cells were also increased in tumors. Furthermore, higher intratumoral IL-22CD4 T-cell percentage and Th22-cell percentage were found in patients with tumor-node-metastasis stage advanced and predicted reduced overall survival. In conclusion, our data indicate that IL-22CD4 T cells and Th22 cells are likely important in establishing the tumor microenvironment for GC; increased intratumoral IL-22CD4 T cells and Th22 cells are associated with tumor progression and predict poorer patient survival, suggesting that tumor-infiltrating IL-22CD4 T cells and Th22 cells may be suitable therapeutic targets in patients with GC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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