Pregnancy Outcome Following Exposure to Topical Retinoids: A Multicenter Prospective Study.

Autor:	Panchaud, Alice, Csajka, Chantal, Merlob, Paul, Schaefer, Christof, Berlin, Maya, De Santis, Marco, Vial, Thierry, Ieri, Alessandra, Malm, Heli, Eleftheriou, Georgios, Stahl, Bracha, Rousso, Philippe, Winterfeld, Ursula, Rothuizen, Laura E., Buclin, Thierry
Předmět:	HUMAN abnormalities ANALYSIS of variance CONFIDENCE intervals EPIDEMIOLOGY FISHER exact test INTERVIEWING LONGITUDINAL method EVALUATION of medical care MEDICAL cooperation SCIENTIFIC observation PREGNANCY QUESTIONNAIRES RESEARCH RETINOIDS SKIN diseases T-test (Statistics) LOGISTIC regression analysis DATA analysis DATA analysis software DESCRIPTIVE statistics
Zdroj:	Journal of Clinical Pharmacology; Dec2012, Vol. 52 Issue 12, p1844-1851, 8p
Abstrakt:	Concerns have been raised about the use of topical retinoids since the publication of isolated cases of characteristic retinoid embryopathy, originally described after oral use. A collaborative study of the European Network of Teratology Information Services was carried out to evaluate the rate of congenital malformations following first-trimester topical retinoid exposure. A population of 235 exposed pregnant women was compared with 444 controls. No significant differences were observed between groups with regard to the rates of spontaneous abortion (odds ratio [95% confidence interval], 1.5 [0.8-2.7]), minor birth defects (1.3 [0.4-3.7]), and major birth defects (1.8 [0.6-5.4]). No child showed features of retinoid embryopathy. The rate of elective termination in the exposed group was increased 3-fold (3.4 [1.5-7.8]). In conclusion, these results do not suggest an increased risk of retinoid embryopathy. However, according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable. [ABSTRACT FROM PUBLISHER]
Databáze:	Complementary Index
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