A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy.
| Autor: | Auinger, Annegret, Helwig, Ulf, Pfeuffer, Maria, Rubin, Diana, Luedde, Mark, Rausche, Tim, Eddine El Mokhtari, Nour, Fölsch, Ulrich R., Schreiber, Stefan, Frey, Norbert, Schrezenmeir, Jürgen |
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| Předmět: |
HEART failure
GLUCOSE metabolism HEART ventricle diseases ANALYSIS of variance BLOOD pressure BLOOD sugar CARRIER proteins CHI-squared test FASTING FAT content of food GENETIC polymorphisms GENETIC research GLUCOSE tolerance tests LEFT heart ventricle diseases HEART ventricles INGESTION INSULIN LONGITUDINAL method MYOCARDIUM PROBABILITY theory QUESTIONNAIRES RESEARCH funding TRIGLYCERIDES U-statistics LOGISTIC regression analysis DATA analysis software METABOLIC syndrome GENETICS |
| Zdroj: | British Journal of Nutrition; 5/28/2012, Vol. 107 Issue 10, p1422-1428, 7p |
| Abstrakt: | Fatty acid transport protein 6 (FATP6) is primarily expressed in the heart and seems to be involved in cardiac fatty acid uptake. Therefore, we investigated whether a variation in the 5′-untranslated region of the FATP6 gene is associated with features of the metabolic syndrome and signs of myocardial alteration or heart failure. A total of 755 male participants from a Metabolic Intervention Cohort Kiel were genotyped for the FATP6–7T>A polymorphism (rs2526246) and phenotyped for features of the metabolic syndrome. Participants underwent a glucose tolerance test and the postprandial assessment of metabolic variables after a standardised mixed meal. Left ventricular heart function was evaluated in fifty-four participants. Fasting (P = 0·01) and postprandial (P = 0·02) TAG concentrations were significantly lower in AA homozygotes when compared with wild-type carriers. Homozygosity of allele A was associated with significantly lower postprandial insulin concentrations after a glucose load and significantly lower systolic (P = 0·01) and diastolic (P = 0·01) blood pressure values compared with wild-type carriers. Accordingly, left ventricular heart mass was significantly lower in twenty-seven AA homozygotes in comparison with twenty-seven TT homozygotes, matched for BMI (P = 0·04). In conclusion, the effects of the FATP6 polymorphism on TAG are mediated by affluent dietary fat. The FATP6–7T>A polymorphism may protect from traits of the metabolic syndrome and CVD. [ABSTRACT FROM PUBLISHER] |
| Databáze: | Complementary Index |
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