| Autor: |
Labarta, José I., Moreno, Maria L., López-Siguero, Juan P., Luzuriaga, Cristina, Rica, Itxaso, Sánchez-del Pozo, Jaime, Gracia-Bouthelier, Ricardo |
| Předmět: |
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| Zdroj: |
European Journal of Endocrinology; Oct2012, Vol. 167 Issue 4, p523-529, 7p |
| Abstrakt: |
Context: Oestrogen induction of pubertal changes in Turner girls may reinforce their psychological well-being and may also optimise final height; however, oestrogen type, dose, and route are not well established. Objective: To induce normal pubertal development in Turner girls and ovarian insufficiency with oral 17α-oestradiol (E2), either as individualised dose (ID) or as fixed dose (FD), and to determine whether growth is affected. Design: Open-label randomised, parallel groups, multicentre clinical trial in 48 GH-treated Turner girls. Oral E2 was given in tablets, either as an ID of 5-15 μg/kg per day during 2 years or as a FD of 0.2 mg daily during the first year followed by 0.5 mg daily during the second year. Main outcome measures were the event of attaining a Tanner breast staging ≥4 (primary), FSH, and auxological variables (secondary). Results: Shorter median time to Tanner staging ≥ B4 in the FD group (733 days) compared with the ID group (818 days) (PZ0.046). Higher proportion of girls with Tanner staging ≥ B4 (65%) in the FD group compared with the ID group (42%) (PZ0.068). Bone age did not show inadequate acceleration and adult height prediction was maintained in both groups. No oestrogen-related adverse events were reported. Conclusions: Two-year treatment with oral E2 can progressively induce normal pubertal development in Turner syndrome. Low-dose oral E2 given as a FD produces a satisfactory pubertal development not inferior to ID. Treatment was well tolerated and did not interfere with the growth-promoting effect of GH. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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