Effect of Gonadectomy on Activity of Neuronal 3β-Hydroxysteroid Dehydrogenase in Some Brain Structures.

Autor:	Ryzhavskii, B., Zadvornaya, O.
Předmět:	DEHYDROGENASES NEURAL physiology CASTRATION BRAIN physiology EXPERIMENTAL biology
Zdroj:	Bulletin of Experimental Biology & Medicine; Sep2012, Vol. 153 Issue 5, p784-786, 3p
Abstrakt:	3β-Hydroxysteroid dehydrogenase is a key enzyme in the synthesis of steroid hormones in steroid-producing organs, including the brain producing neurosteroids. 3β-Hydroxysteroid dehydrogenase activity can be a marker of steroid-producing cells. We present the results of histochemical assay of this enzyme in the neocortex, hippocampus, and cerebellar cortex of go nadectomized prepubertal rats. The positive reaction was detected in hippocampal neurons, ganglionic layer cells of the cerebellar cortex (Purkinje cells), and solitary neocortical neurons of male and female rats. Gonadectomy signifi cantly increased enzyme activity in neocortical (layer V) and hippocampal neurons and had no effect on the intensity of the reaction in Purkinje cells. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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