| Autor: |
Stankova, Ivanka, Stanoeva, Kamelia, Hinkov, Anton, Alexiev, Ivailo, Genova-Kalou, Petya, Chayrov, Radoslav, Argirova, Radka |
| Zdroj: |
Medicinal Chemistry Research; Dec2012, Vol. 21 Issue 12, p4053-4059, 7p |
| Abstrakt: |
Abacavir (ABC) is clinically associated with hypersensitivity reactions, risk for cardiovascular disease, etc. A possible way to minimize side effects is by modifying chemical structure. Three esters of ABC containing amino acid (glycine) and dipeptide esters (glycyl-glycine) were synthesized and their activity on HIV-1 III B replication in MT-4 cells was evaluated. One of the newly synthesized esters-Gly-ABC-demonstrates low-cytotoxicity and high-anti-HIV-1 activity in MT-4 cells, as well as low-mitochondrial toxicity and high-genetic barrier to resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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