| Autor: |
Thakurta, Rajarshi Guha, Das, Ranjan, Bhattacharya, Amit Kumar, Saha, Debasish, Sen, Sreyashi, Singh, Om Prakash, Bisui, Bikash |
| Předmět: |
|
| Zdroj: |
Indian Journal of Psychological Medicine; Apr-Jun2012, Vol. 34 Issue 2, p170-175, 6p, 1 Chart, 4 Graphs |
| Abstrakt: |
Context: Suicidal ideation in depressed patients is a serious and emergent condition that requires urgent intervention. Intravenous ketamine, an N-methyl-D-aspartate (NMDA) antagonist, has shown rapid antidepressant effects, making it a potentially attractive candidate for depressed patients with suicidal risk. Aims: In India few studies have corroborated such findings; the present study aimed to assess the effectiveness and sustainability of antisuicidal effects of ketamine in subjects with resistant depression. Settings and Design: Single-center, prospective, 4 weeks, open-label, single-arm pilot study. Materials and Methods: Twenty-seven subjects with DSM-IV major depression (treatment resistant) were recruited. The subjects were assessed on Scale for Suicidal Ideation (SSI), 17-item Hamilton Depression Rating Scale (HDRS). After a 2-week drug-free period, subjects were given a single intravenous infusion of ketamine hydrochloride (0.5 mg/kg) and were rated at baseline and at 40, 80, 120, and 230 minutes and 1 and 2 days postinfusion. Results: The ketamine infusion was effective in reducing the SSI and HDRS scores, the change remained significant from minute 40 to 230 at each time point. Conclusions: The real strength of this study rests in documenting the rapid albeit short-lasting effect of ketamine on suicidal ideation in depressed patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
