| Autor: |
Sun, Xian-Yu, He, Xian-Jing, Pan, Chun-Yuan, Liu, Yan-Peng, Zou, Yun-Peng |
| Zdroj: |
Medicinal Chemistry Research; Nov2012, Vol. 21 Issue 11, p3692-3698, 7p |
| Abstrakt: |
In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5- a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5- a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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