| Autor: |
Wu, Herren, Beuerlein, Gregory, Ying Nie, Smith, Heidi, Lee, Bruce A., Hansler, Mary, Huse, William D., Watkins, Jeffry D. |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 05/26/98, Vol. 95 Issue 11, p6037, 6p, 3 Charts, 4 Graphs |
| Abstrakt: |
Gives information on the development of a protein engineering strategy bases on efficient and focused mutagenesis implemented by codon-based mutagenesis, with reference to the use of Vitaxin, a humanized version of the antiangiogenic antibody LM609. Regulation of angiogenesis; Characteristics of vitaxin; Methodology used in the development process; Construction of CDR libraries; Results of the study. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
