| Autor: |
Schervish, E., O'Connell, J. B., Kowalczyk, D., Robinson, J. A. |
| Zdroj: |
European Heart Journal; 1987, Vol. 8 Issue suppl_J, p141-143, 3p |
| Abstrakt: |
There is conflicting evidence for a defect in mononuclear suppressor function(s) in dilated cardiomyopathy (DC). In order to assess immunoregulation in patients with DC, mononuclear suppressor cell inducibility was determined by a standard in vitro assay. Peripheral mononuclear cells (PMC) from 20 normals and 27 patients with DC were stimulated with Concanavalin-A (Con-A) in vitro for 2 days to activate suppressor cell populations, washed with α-methylmannoside, then co-cultured with autologous lymphocytes that were already undergoing lectin-induced or allogeneic stimulation in mixed lymphocyte culture.The expected absence of Con-A inducible suppressor cell activity was found in patients with systemic lupus erythematosus (SLE). There was no significant defect in the ability of PMC from DC to attenuate an established mitogen or allogeneic proliferative reaction when compared to normals. These data, in contrast to the initial DC suppressor studies by others, provide further support fornormal in vitro PMC suppressor function in DC. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
