| Autor: |
Fogelson, Bernard G., Nawas, Sammy I., Vigneswaran, Wickii T., Ferguson, James L., Law, William R., Sharma, Avadhesh C., Fogelson, B G, Nawas, S I, Vigneswaran, W T, Ferguson, J L, Law, W R, Sharma, A C |
| Předmět: |
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| Zdroj: |
Diabetes; Jul1998, Vol. 47 Issue 7, p1161-1163, 3p, 2 Charts, 1 Graph |
| Abstrakt: |
Diabetes is associated with altered vascular responses, and diabetic patients demonstrate increased morbidity and mortality after coronary artery bypass grafting (CABG). We tested whether endothelin (ET)-1 levels in this patient population differed from those in nondiabetic subjects after CABG. Of 14 consecutive patients who underwent CABG by the same surgeon, 7 had type 2 diabetes and 7 were nondiabetic. The two groups did not differ significantly in preoperative ejection fraction, number of vessels bypassed, cross-clamp time, or Parsonnet's score. Coronary sinus blood samples were obtained before cardioplegic arrest and then obtained at 1 and 15 min after each of two reperfusion periods: reperfusion A (native coronary perfusion plus the left internal mammary artery), reperfusion B (saphenous vein graft perfusion). ET-1 was significantly increased at all reperfusion time points in diabetic patients compared with nondiabetic patients. In diabetic patients, reperfusion after CABG can trigger the release of ET-1, which may be a contributing factor in the increased cardiac morbidity seen in this patient population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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