| Autor: |
Cutler, Ralph E., Blair, Andrew D., Burgess, Ellen D., Parks, Donald |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1982, Vol. 10 Issue suppl_C, p91-97, 7p |
| Abstrakt: |
Twenty-five subjects, divided into four groups according to their creatinine clearance, each received a 0.5 g intravenous dose of ceftizoxime over 1 to 2 min in order to determine the pharmacokinetics of parenteral ceftizoxime in subjects with various degrees of renal insufficiency and of high doses of parenteral ceftizoxime in subjects with normal renal function. Blood and urine samples were taken periodically and measured for drug concentration (in serum, by well-plate diffusion and in urine, by high performance liquid chromatography). The mean pharmacokinetic parameters were calculated, and the data compared. Ceftizoxime's relatively small steady-state volume of distribution throughout the body is not altered in renal disease. No concentration-dependent kinetics are indicated since the data did not vary significantly over a wide dosage range. Ceftizoxime is eliminated primarily by the kidneys and has a prolonged serum half-life in patients with end-stage renal disease so that dosage should be adjusted for patients with moderate-to-severe renal impairment. The protein binding of ceftizoxime in subjects with normal renal function is 31%; the haemodialysis clearance of ceftizoxime is 44.8 ± 21.5 ml/min. Supplemental dosage of ceftizoxime is not necessary after haemodialysis. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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