| Autor: |
Nikiforov, A. I., Lippmann, M., Palmes, E. D. |
| Zdroj: |
Annals of Occupational Hygiene; 1998 Inhaled Particles VI, Vol. 32, p33-39, 7p |
| Abstrakt: |
Structural changes of the small airways (< 2 mm diameter) and the pulmonary airspaces occur early in the pathogenesis of chronic obstructive pulmonary diseases (COPD). We have previously shown that the rate of deposition of a monodisperse aerosol during breath holding can be used to determine a mean effective airspace dimension (MEAD) for lung airways. While in vivo MEADs were consistent with morphometric models of the human lung, direct confirmation of the method with morphometric measurements in the same lungs was lacking. Experiments in excised human lungs were initiated to validate the method and to determine the influence of various lung dimensional indices on the parameters obtained from the aerosol probe measurements. Strong correlations were found between aerosol and morphometric indices in a group of 23 lungs, providing increased confidence for applications of aerosol probes in epidemiological and clinical evaluations. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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