| Autor: |
Howorka, Kinga, Pumprla, Jiri, Haber, Paul, Koller-Strametz, Jeanette, Mondrzyk, Jerzy, Schabmann, Alfred |
| Zdroj: |
Cardiovascular Research; Apr1997, Vol. 34 Issue 1, p206-214, 9p |
| Abstrakt: |
Objective: To investigate the effects of regularly performed endurance training on heart rate variability in diabetic patients with different degrees of cardiovascular autonomic neuropathy (CAN). Methods: Bicycle ergometer training (12 weeks, 2×30 min/week, with 65% of maximal performance) was performed by 22 insulin-requiring diabetic patients (age 49.5±8.7 years; diabetes duration 18.6±10.6 years; BMI 25.1±3.4 kg/m2): i.e., by 8 subjects with no CAN, 8 with early CAN and by 6 patients with definite/severe CAN. A standard battery of cardiovascular reflex tests was used for grading of CAN, a short-term spectral analysis of heart rate variability for follow-up monitoring of training-induced effects. Results: While the training-free interval induced no changes in spectral indices, the 12-week training period increased the cumulative spectral power of the total frequency band (P=0.04) but to a different extent (P=0.039) in different degrees of neuropathy. In patients with no CAN the spectral power in the high-frequency (HF) band (0.15–0.50 Hz) increased from 6.2±0.3 to 6.6±0.4 ln [ms2]; P=0.016, and in the low-frequency (LF) band (0.06–0.15 Hz) from 7.1±0.1 to 7.6±0.3 ln [ms2]; P=0.08, which resulted in an increase of total spectral power (0.06–0.50 Hz) from 7.5±0.1 to 8.0±0.3 ln [ms2] (P=0.05). Patients with the early form of CAN showed an increase of spectral power in HF (5.1±0.2 to 5.8±0.1 ln [ms2], P=0.05) and LF bands (5.6±0.1 to 6.3±0.1 ln [ms2], P=0.008), resulting in an increase of total power from 6.1±0.1 to 6.6±0.1 ln [ms2] (P=0.04), whereas those with definite/severe CAN showed no changes after the training period. Training improved fitness in the whole patient cohort. The increased autonomic tone as assessed by spectral indices disappeared after a training withdrawal period of 6 weeks. Conclusions: In diabetic patients with no or early CAN, regularly performed endurance training increased heart rate variability due to improved sympathetic and parasympathetic supply, whereas in subjects with definite/severe CAN no effect on heart rate variability could be demonstrated after this kind of training. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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