| Autor: |
BURNAM, MICHAEL H, SETHNA, DHUN H, ROSE, DANIEL M, STERN, CRAIG S, SHELL, WILLIAM E |
| Zdroj: |
Cardiovascular Research; Apr1981, Vol. 15 Issue 4, p239-244, 6p |
| Abstrakt: |
Myocardial β-adrenoceptor binding was investigated, with (−)3H dihydroalprenolol as radioligand, in microsomes derived from anterior (ALV) and inferior (ILV) myocardial wall sections of the canine left ventricle. Characterisation of specific binding sites revealed a hierarchy of myocardial β-adrenoceptor binding with greater binding occurring to the anterior than the inferior wall of the left ventricle, under identical experimental conditions. Equilibrium analysis by Scatchard plots suggested a significant (P < 0.01) difference in the number of receptors (Bmax ALV = 70 fmol·mg−1 protein vs Bmax ILV = 37 fmol·mg−1 protein) with no alteration in the binding affinity of the receptors (KDALV = 10.1 nmol·litre−1 vs KDILV = 6.7 nmol·litre−1). Such differences in the extent of binding of β-adrenoreceptors in cardiac muscle may be of physiological and pathological significance and may account for the heterogeneity of regional autonomic responses in the heart. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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