| Autor: |
Iravani, Abdollah, Klimberg, Ira, Briefer, Caesar, Munera, Catherine, Kowalsky, Steven F., Echols, Roger M. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1999, Vol. 43 Issue suppl_1, p67-75, 9p |
| Abstrakt: |
The study was undertaken to compare the safety and efficacy of twice-daily ciprofloxacin for 3days with standard 7 day therapy with either co-trimoxazole or nitrofurantoin in the treatment ofwomen with acute, uncomplicated urinary tract infections (UTI). This multicentre, prospective,randomized, double-blind trial compared oral ciprofloxacin (100 mg bd) for 3 days with co-trimoxazole (160/800 mg bd) or nitrofurantoin (100 mg bd) for 7 days. Bacteriological andclinical evaluations were performed at study entry, during therapy and 4-10 days and 4-6 weeksafter the completion of therapy. The primary efficacy parameter was eradication of the causativeorganism 4- 10 days following treatment. Of 713 women enrolled and evaluable for safety, 521were evaluable for efficacy (168 ciprofloxacin, 174 co-trimoxazole, 179 nitrofurantoin). Escherichia coli (83%) was the most frequently isolated pathogen in all treatment groups.Bacteriological eradication was reported in 88% of ciprofloxacin patients, 93% of co-trimoxazolepatients and 86% of nitrofurantoin patients. At the 4-6 week follow-up, ciprofloxacin hadstatistically significantly higher eradication rates (91%) than co-trimoxazole (79%; 95%confidence limit (CL) = −20.6%, −3.9%) and nitrofurantoin (82%; 95%CL = −17.1%, −0.9%). Clinical resolution 4- 10 days after therapy and atthe 4- 6 week follow-up wassimilar among the three treatment groups. The overall incidence of treatment-emergent adverseevents was not significantly different (P= 0.093) among the three drug regimens,althousgh co-trimoxazole was associated with a greater number of adverse events thanciprofloxacin (P ≤0.05). Ciprofloxacin also caused fewer episodes of nausea thaneither of the other agents (P ≤0.01). [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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