| Autor: |
DHALLA, N. S., SULAKHE, P. V., KHANDELWAL, R. L., OLSON, R. E. |
| Zdroj: |
Cardiovascular Research; Jul1972, Vol. 6 Issue 4, p344-352, 9p |
| Abstrakt: |
The basal adenyl cyclase activities of the homogenate and washed cell particles of rat hearts perfused with substrate-free medium for 2 hr were lower than those in hearts perfused with medium containing glucose. The activation of adenyl cyclase in the homogenate and particulate fraction by sodium fluoride as well as adrenaline was markedly reduced in substrate- depleted hearts. The ability of adrenaline to increase the output of lactate and glycerol was decreased on perfusing the heart with substrate-free medium for a period of 2 hr. Adrenaline-induced increase in surface fluorescence due to reduced pyridine nucleotides and contractile force of the heart was also depressed by perfusion with substrate-free medium. These results indicate the role of exogenous substrate in the maintenance of adenyl cyclase activity in the myocardium. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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