| Autor: |
Brisson, A.M., Fourtillan, J. B. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1982, Vol. 10 Issue suppl_B, p11-15, 5p |
| Abstrakt: |
A reversed-phase high-performance liquid-chromatographic assay method was used to study pharmacokinetics of cefadroxil in healthy adults following administration of a single dose of 500 mg, a single dose of 1 g and, in a randomized cross-over study, three repeated doses of 500 mg and two repeated doses of 1 g. This rapid and specific method permitted the detection of 150 μg/l in plasma samples.The disposition kinetics appeared to follow a two-compartment open model with a difference in terminal plasma half-life between administrations of 500 mg and 1 g. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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