| Autor: |
Meyer, B. H., Muller, F.O., Luus, H. G., Drees, B., Röthig, H. J., Badian, M., Eckert, H. G. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1992, Vol. 29 Issue suppl_A, p63-70, 8p |
| Abstrakt: |
The pharmacokinetics of cefpirome were studied in healthy male subjects following single (0·5, 1·0 and 2·0 g) and multiple (1·0 g every 12 h for 3·5 days) intramuscular injections. High pressure liquid chromatography was used to determine cefpirome concentrations in plasma and urine. Cefpirome was absorbed rapidly, mean peak times were 1·6–2·3 h. Pharmacokinetics were linear over the 0·5 to 2·0 g range with mean total body clearance ranging from 148 to 154 mL/min. The peak plasma concentration and area under the curve increased in a dose proportional manner. The terminal half-life (2 h) was not influenced by dose or duration of dosing. There was no drug accumulation after multiple im administrations. About 70–80% of an administered dose was excreted in the urine as unchanged cefpirome. Cefpirome was well tolerated, slight to moderate pain being reported in less than 30% of the injections. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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