| Autor: |
Stobberingh, E. E., Houben, A. W., van Boven, C. P. A. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1985, Vol. 15 Issue suppl_C, p73-83, 11p |
| Abstrakt: |
The in-vitro activity of Sch 34343, a derivative of Sch 29482, was assessed and compared with that of other β-lactam antibiotics. Nearly all Enterobacteriaceae, including ampicillin-resistant strains (MIC ≥256 mg/1) were inhibited at concentrations ranging from 0.125–8 mg/1. The geometric mean MIC values varied from 0.25 mg/1 to 2.4 mg/1 for Klebsiella and Serratia spp., respectively. Sch 34343 did not inhibit Pseudomonas aeruginosa. The antibacterial activity was minimally altered by changes of medium or inoculum size. The results suggest high stability against plasmid- and chromosomally-mediated β-lactamases. However, crude extracts of four Pseudomonas strains did hydrolyse Sch 34343. In addition to the high antibacterial activity and the β-lactamase stability, Sch 34343 markedly inhibited most plasmid- and chromosomally-mediated β-lactamases, with the exception of PSE-1 and PSE-4. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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