| Abstrakt: |
Rapid reduction in plasma potassium concentration was induced in anaesthetized dogs with an infusion of glucose and insulin. These animals, and a group of normal dogs, were given 100 μCi 3H-digoxin intravenously. The glucose-insulin infusion caused a reduction in plasma potassium and an increase in ventricular myocardial potassium content, although there was no significant change in skeletal muscle potassium. With these changes there was a marked increase in 3H-digoxin level in ventricular and skeletal muscle, and in the bile and urine. Reduction in extracellular potassium level increased the uptake of digoxin by skeletal and myocardial muscle, and excretion in bile and urine, possibly by freeing receptor sites on the outer surface of the membrane of these cells, and permitting the increased uptake of the glycoside by myocardial and skeletal muscle cells, and also hepatic and renal cells. [ABSTRACT FROM PUBLISHER] |
