Lecithin:Cholesterol Acyltransferase Is Insufficient to Prevent Oxidative Modification of Low-Density Lipoprotein.

Autor: Murakami, Youhei, Kamiyama, Shin, Howlader, Zakir H., Yamato, Tokuhisa, Komai, Michio, Furukawa, Yuji
Předmět:
Zdroj: Journal of Biochemistry; 2002, Vol. 131 Issue 1, p17-19, 3p
Abstrakt: We tried to confirm the antioxidative capability of lecithin:cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976–5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index