| Autor: |
Jensen, Tim, Lanng, Susanne, Faber, Mette, Rosdahl, Vibeke Thamdrup, Høiby, Niels, Koch, Christian |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1990, Vol. 25 Issue suppl_B, p45-52, 8p |
| Abstrakt: |
A survey of Staphylococcus aureus lung infection in 243 patients with cystic fibrosis (CF) was conducted between 1986 and 1988. A total of 217 patients (89%) received 1605 courses of anti-staphylococcal therapy given during this period. The majority of courses comprised combined therapy with two anti-staphylococcal drugs. The combination of dicloxacillin and fusidic acid was employed most frequently. Some patients were given other anti-staphylococcal regimens, because of penicillin allergy (14 cases) or dyspeptic side effects with fusidic acid (21 patients). A small but significant increase in precipitins against S. aureus was observed during the study period. Bacterial resistance to the anti-staphylococcal drugs used remained at a low level (strains resistant to methicillin < 0.1%, strains resistant to fusidic acid 1.2%). When the isolates were compared with 56,140 strains of S. aureus isolated from non-CF patients hospitalized in Denmark over the same period, no differences in phage-types or in antibiotic resistance were seen, indicating that selection of strains and cross infection do not seem to be a major problem in CF patients. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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