| Autor: |
Hare, R. S., Miller, G. H., Naples, L., Sabatelli, F., Loebenberg, D., Waitz, J. A. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1982, Vol. 9 Issue suppl_C, p7-16, 10p |
| Abstrakt: |
A new penem antibiotic, Sch 29482 (SCH), was shown to be active against a large number of Gram-negative and Gram-positive isolates. SCH was, in general, eightfold less potent than cefotaxime against sensitive Gram-negative organisms, but eightfold more potent against staphylococci. For SCH, the ratio of MICs against cephalothinsensitive strains to those against cephalothin-resistant strains was lower than any other tested compound, indicating SCH had good activity against many β-lactamase containing strains. Only against cefoperazone-resistant Serratia and ampicillin resistant Staphylococcus did SCH show a loss of activity. A very small inoculum size effect was observed with both β-lactam-sensitive and -resistant strains. Among 216 strains tested, only a few had higher MICs with SCH in broth media than on agar media. These results suggest that SCH has unusual stability to most β-lactamases. The activity of SCH was not significantly affected by different broth constituents nor by pH changes in the range of 6.5−7.9. Increases in MICs caused by the addition of 4% BSA to the test medium indicate that serum protein binding may be greater than 90%. The bactericidal activity of SCH against both Gram-negative and Gram-positive strains was superior to that observed with cefoxitin and cefotaxime. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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