| Autor: |
DiPiro, Joseph T., Welage, Lynda S., Levine, Barry A., Wing, Patricia E., Stanfield, Johnny A., Gaskill, Harold V., Scarfoni, Deborah S., Schentag, Jerome J., Bowden, Talmadge A., Williams, James S. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1989, Vol. 23 Issue suppl_D, p71-77, 7p |
| Abstrakt: |
One hundred and ninety-five patients undergoing abdominal surgical procedures completed a multicentre, randomized, open-label study comparing the safety and efficacy of cefmetazole and cefoxitin for the prevention of postoperative wound infection. Cefmetazole was administered iv in a single 2 g dose given within 90 min of the operation. Cefoxitin was administered in a single 2 g, similarly timed, preoperative dose and two additional doses given at 6 h intervals after surgery. For operations that exceeded 2–4 h duration an additional dose of each agent was administered. Patients undergoing colorectal operations received oral neomycin and erythromycin as bowel preparation. Colorectal operations were performed most frequently (49% of patients) followed by cholecystectomies (26%) and gastroduodenal procedures (21%). The operative site infection rate was 6–5% for cefmetazole and 7.7% for cefoxitin (P >0.05). Serious drug related adverse effects were not observed. This study demonstrates that administration of single-dose cefmetazole is as effective as a standard three dose regimen of cefoxitin for prophylaxis with abdominal operations. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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