| Autor: |
Baily, Robert G, Lehman, Joy C, Gubin, Steven S, Musch, Timothy I |
| Zdroj: |
Cardiovascular Research; May1993, Vol. 27 Issue 5, p851-855, 5p |
| Abstrakt: |
Objective: The aim was to evaluate whether two dimensional echocardiographic/Doppler (echo/Doppler) techniques could be used to detect left ventricular damage rapidly, accurately, and non-invasively in rats with a myocardial infarction. Methods: Female Wistar rats were initially subjected to either a sham operation or surgery to induce a myocardial infarct by ligating the left main coronary artery. Following a minimum of six weeks to recover from the surgery, all rats were reanaesthetised and cardiac and stroke indexes were determined at similar heart rates, using echo/Doppler techniques. Postmortem histological assessment of myocardial infarct size was compared with the non-invasive detection of left ventricular wall motion abnormalities, left ventricular dilatation, and the presence of a left ventricular aneurysm found in the living animal. Results: Rats with myocardial infarction (n=8) showed a 33(SEM 4)% reduction (p < 0.01) in cardiac index (due to a 33% reduction in stroke index) when compared to their non-infarcted counterparts (n=5). In addition, a significant correlation (r=0.84; n=25; p < 0.01) was found between the assessment of left ventricular damage via non-invasive echo/ Doppler measurements and the histological determination of infarct size. Conclusions: These results support the conclusion that two dimensional echo/Doppler techniques can be used to estimate rapidly and non-invasively the degree of left ventricular damage produced in living rats with myocardial infarction when compared to non-infarcted controls.Cardiovascular Research 1993;27:851-855 [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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