| Autor: |
Dow, J., Chazal, J., Frydman, A. M., Janny, P., Woehrle, R., Djebbar, F., Gaillot, J. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1986, Vol. 17 Issue suppl_B, p81-87, 7p |
| Abstrakt: |
Nine subjects (5 women) aged between 17–66 years, with hydrocephalus were studied. An external ventricular drain was introduced for diagnostic purposes. Cerebro-spinal fluid (CSF) and plasma samples were obtained at suitable intervals after 1 h infusion of 400 mg pefloxacin. In plasma, pefloxacin Cmax was 8.54±1.53 (mean±S.E.M.) mg/1, at the end of infusion, whereas N-desmethyl pefloxacin concentration was 0.17±0.03 mg/1. The metabolite accounted for only 2% of plasma levels of pefloxacin. In CSF, pefloxacin Cmax was 2.97±0.32 mg/1, 5–6 h after the start of infusion, whereas N-desmethyl pefloxacin Cmax varied between 0.1–0.2 mg/1. Apart from the 1 h sample, the CSF/plasma ratio of pefloxacin was 60% which is similar to the unbound fraction of pefloxacin in plasma. The apparent half-life (T½) of transfer of pefloxacin from plasma to CSF was 1.26±0.18 h, assuming a first order process, while the apparent elimination T½/2 in CSF was 13.40±1.76 h, which is similar to the elimination T½ found previously in plasma, thus accumulation of pefloxacin in CSF is unlikely. With the present dosage regimen, CSF quickly attains therapeutic levels of pefloxacin. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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