| Autor: |
Hermida, Jean-Sylvain, Denjoy, Isabelle, Jarry, Geneviève, Jandaud, Serge, Bertrand, Cathy, Delonca, Jean |
| Zdroj: |
EP: Europace; 2005, Vol. 7 Issue 5, p447-453, 7p |
| Abstrakt: |
Aim To identify ECG predictors of Brugada type response during Na channel blockade challenge. Methods We studied prospectively 103 patients (M=76, 45±13 years) in whom ECGs were collected during ajmaline challenge. ECG recordings included the high right precordial leads (−2V1 and −2V2). A positive response was defined by a >0.2 mV J point or ST segment elevation and a down-sloping pattern of the ST segment in at least one right precordial lead. Results Ajmaline challenge was positive in 48 (47%) of the 103 cases. Baseline J wave elevation was greater in −2V1 (0.077±0.078 mV vs. 0.038±0.046 mV, P=0.003) and −2V2 (0.149±0.103 mV vs. 0.043±0.088 mV, P<0.001) in cases with a subsequent positive response. In contrast, ST segment elevation and T wave amplitudes were reduced in V1, V2 and V3. Logistic regression showed that J wave elevation in −2V2 and decreased T wave amplitude in V3 at baseline were independent predictors of a positive response. Baseline J wave elevation >0.16 mV in −2V2 had a specificity of 100%, a sensitivity of 40%, a positive predictive value of 100% and a negative predictive value of 28%. Conclusion J wave elevation >0.16 mV in −2V2 was the strongest predictor of a Brugada type response to Na channel blockade challenge when Brugada syndrome was suspected on a baseline ECG. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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