| Autor: |
Crokaert, F., Potvliege, C., Vanderlinden, M. P., Glupczynski, Y., Yourassowsky, E. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1981, Vol. 8 Issue suppl_B, p325-329, 5p |
| Abstrakt: |
Ceftazidime was evaluated as an antipseudomonal drug, in a non-comparative study including 10 men and 4 women, at a daily dose of 3–6 g/day iv or im for 4 days. Bacteriological eradication was initally obtained in 13 patients (93%), but 1 patient did not significantly improve, and 1 failure and 4 relapses occurred. Follow up was not adequate in 2 patients, so definite cure was obtained in 7/12 patients (58.3%). The drug was withdrawn in one case because of a severe rash; other side-effects were minimal and reversible.All the organisms were susceptible to ceftazidime (mean MIC 1.72mg/l). Mean serum levels of ceftazidime were 2 mg/l at the trough and 55.7 mg/l (range 48–70) 30 min after iv injection, and after 1 g im 5.1 mg/l (2–12.5 and 34.1 mg/l (18–48), respectively. A good correlation was generally observed between serum activity, serum values and MICs. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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