| Autor: |
Reiner, Neil E., Bloxham, Don D., Thompson, W. Leigh |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); 1978, Vol. 4 Issue suppl_A, p85-101, 17p |
| Abstrakt: |
Forty female mongrel dogs were allocated randomly to treatment with gentamicin or tobramycin, 45 mg/kg/day, by continuous intravenous infusion or once daily intravenous injection for 10 days. Serum aminoglycoside clearances were measured daily and compared on the first and tenth days with urine clearances of exogenous creatinine and aminoglycoside. On the first day of therapy mean serum aminoglycoside concentrations averaged 9.3 mg/1 and all three clearances averaged 3.9 mg/kg/min. During the 10 days of therapy these three clearances decreased an average of 48 %, but nephrotoxicity was much greater in dogs given continuous intravenous infusions and in those given gentamicin. On the tenth day tissue concentrations of gentamicin in the outer renal cortex averaged 1877 μg/g and were greater than renal cortical concentrations of tobramycin that averaged 994 μg/g. Tissue aminoglycoside concentrations were equal in dogs receiving once daily or continuous therapy. Despite causing momentary peak serum concentrations of amino-glycosides of 200 to 500 mg/1, once daily intravenous injection was significantly less nephrotoxic than continuous intravenous infusion, and tobramycin was less nephrotoxic than gentamicin in equivalent doses. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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